Superdisintegrants

For tablets and capsules which need rapid disintegration, the inclusion of the right disintegrant is a prerequisite for optimal bioavailability. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate.

Superdisintegrants are widely used in Direct Compression and Wet Granulation applications. In order to closely match the functionality requirements, DMV-Fonterra Excipients produces two superdisintegrants: Primojel®, sodium starch glycolate, and Primellose®, croscarmellose sodium, which show outstanding disintegration characteristics for tablets prepared by Direct Compression, Wet Granulation and for capsule formulations.

Sodium starch glycolate

Primojel® is the leading brand of sodium starch glycolate in the world. A single grade has been optimised for both Direct Compression and Wet Granulation applications to meet your needs in these different technologies.

Recommended product:
» Primojel

Suitable for the applications:
» Direct Compression
» Wet Granulation

Croscarmellose sodium

Primellose® is croscarmellose sodium, a highly versatile superdisintegrant that is effective in a wide range of formulations. It has been optimised for particle size distribution to provide exceptional disintegrating power. It is also highly suitable for use in orally disintegration tablet formulations.

Recommended product:
» Primellose

Suitable for the applications:
» Direct Compression
» Wet Granulation
» Orally Disintegrating Tablets


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