Superdisintegrants

For tablets and capsules which need rapid disintegration, the inclusion of the right disintegrant is a prerequisite for optimal bioavailability. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate.

Superdisintegrants are widely used in direct compression and wet granulation applications. In order to closely match the functionality requirements, DMV-Fonterra Excipients produces two superdisintegrants: Primojel®, sodium starch glycolate, and Primellose®, croscarmellose sodium, which show outstanding disintegration characteristics for tablets prepared by direct compression, wet granulation and for capsule formulations. 



Primojel® & Primellose®
Why should you use Primojel® or Primellose®? Both products are hydrophilic and practically insoluble, which allows increased disintegration of solid dosage forms. Superdisintegrants are effective in low concentrations of 2 % to 6 %, while traditional disintegrants such as starches often require concentrations of about 20 %.

Growing awareness of the cost control in the pharmaceutical industry makes the use of superdisintegrants such as Primojel® and Primellose® even more attractive. The relatively low concentration of the superdisintegrants helps to reduce overall tablet size, or allows inclusion of higher levels of compressible filler-binders (see SuperTab® range of DMV-Fonterra Excipients).