Primojel®

Sodium starch glycolate, USP-NF, Ph. Eur., JP

Description
Primojel® is produced by cross-linking and carboxymethylation of potato starch. It is a white, free-flowing powder.

Disintegration performance
Primojel® takes up more than 20 times its own weight of water. The swelling particles and water penetration into the tablets result in fast disintegration and efficacy. Studies show that Primojel® takes up more water than comparative products on the market and develops a strong disintegrating force making it an highly effective product. The starch source, degree of cross-linking and degree of substitution of Primojel® have been optimised in order to give rapid water uptake by the polymer without the formation of a viscous gel that may impede water penetration into the tablet. The starch source for sodium starch glycolate is important and Chart 1 in our brochure shows that potato starch, the source material for Primojel®, is the preferred type of starch for sodium starch glycolate.

Application
Primojel® is suitable for a variety of tablet and capsule formulations. It is most effective in combination with insoluble to slightly-soluble filler-binders, such as MCC and dicalcium phosphate at a dosage of 2 % to 6 %. In higher concentrations, Primojel® can act as a dissolution enhancing agent. Primojel® is effective when used as intra-granular or extra-granular superdisintegrant, or when divided between these locations.